I just did this and it's the same for me. In monophonic mode with the same settings, I get slightly lower volume and the drive knob pretty much doesn't do anything, in duo-split however, the drive knob clearly makes the sound brighter when turned up and a bit louder.
Hmm, strange behavior, especially about the drive knob. I always wondered why in a a lot of situations drive didn't do much to change the sound. Now I know, it's because I rarely ever use duo-split mode... Surely this is not by design?