was a problem with the alesis multimix driver.
The driver crashes the new plugins (all of them excerpt semv where an error message displays... ) when try to change samplerate or samples from within the standalones.
I cant change any setting from with in the standalones.
When I change it in the alesis control panel also errors occur. Sometimes changes are taken sometimes not.
When I am back in the standalone setting are still unchanged there.
Then I install asio4all et voila, everything is fine with onboard realtek audio, no problems.
F@ck Avid/Alesis, their latest drivers are ages old, no support for their hardware anymore.