The Technical Support desk is pretty much operational, but based on your email address I cannot trace any inquiry yet. If one was posted, please forward the case number by private message.
I cannot turn OFF (in the preferences) the "USE AS VST" options for the various models - by default some are switched ON some switched OFF
Are the ON synths the ARP2600V and the Minimoog-V?
If so, here is the cause: it sounds like you ran the additional installers included in the package, however they are aimed for automatic update purpose only, *not* manual use. I suppose we should have hidden them a bit more deeply.
Now, the solution: erase any ARP2600V and Minimoog-V files and folders on your computer, and possibly reinstall the Laboratory (and only this synth) from the latest update
Please let me know via the regular Tech Support way if still any issue.
All the best,