I also have this problem. I tweaked a bass sound, saved it as a user preset, made an AMAZING tune with it, and now it's not there when I re-open. And I don't know what preset I even started the sound with now. I'm on Mac Lion 10.7.3. Using Cubase Elements 6. I tested it again, saving a preset, saving Cubase, closing and re-opening, and the preset is gone. Can we get a fix for this please?