It's definitely hardware related.
I have tried a number of USB cables, direct to the Mac on different USB ports, via a powered hub but I still get the issue. I have increased the stream buffer in Pro Tools. Same error, The second I disconnect it, it's fine. It doesn't react at all.
What does that file path refer to? If it is a path, it does look like it. It say line 498, does that refer to a plug in buffer or somekind hidden location?