I have the laboratory 49, and was having some similar issues, but am up an running now. If I may be of help, I'll be glad to.
Can you tell me what DAW you are using, and what audio interface?
I'll do my best to share with you what I found success doing in Sonar 8 Producer Edition, creating Track Templates to ensure continuity in routing.
Also, if you can share what operating system, you have, that would be helpful too.
Tell me what the specific challenge is that you are facing and I will try to assist you as best as I can.